Cardiotoxicity of environmental contaminant tributyltin involves myocyte oxidative stress and abnormal Ca2+ handling

Mitochondrial calcium handling and oxidative stress.

42. 43. 44. International Committee on Proteolysis (I.C.O.P.) Newsletter, August, p. 3 Taylor, A., Blondin, B., Davies, K. J. A. and Murakami, K. (1987) Abstr. 4th Int. Cong. Oxygen Radicals, W-20. Murakami, K., Jahngen, J. H., Lin, S. W., Davies, K. J. A. and Taylor, A. (1 989) Free Radical Biol. Med. 8 ,2 17-222 Levine, R. I,., Oliver, C. N., Fulks, R. M. and Stadtman, E. R. (1981) Proc. Natl...

Oxidative Stress – Environmental Induction

Acute Doxorubicin Cardiotoxicity Involves Cardiomyocyte

Despite well-documented cardiotoxic effects, doxorubicin remains a major anticancer agent. To study the role of myocardial apoptosis following doxorubicin administration, male Wistar rats were exposed to 1.25, 2.5, and 5 mg/kg of i.p. doxorubicin and terminated on days 1–7 in groups of five. Doxorubicin caused a significant (P < 0.001) and dose-dependent induction of cardiomyocyte apoptosis at ...

Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

Chemotherapy-induced cardiotoxicity is a serious complication that poses a serious threat to life and limits the clinical use of various chemotherapeutic agents, particularly the anthracyclines. Understanding molecular mechanisms of chemotherapy-induced cardiotoxicity is a key to effective preventive strategies and improved chemotherapy regimen. Although no reliable and effective preventive tre...

Citrus aurantium L. peel extract mitigates hexavalent chromium-induced oxidative stress and cardiotoxicity in adult rats

In the present study, we aimed to examine the potential protective effect of C. aurantinum L. peel extract against oxidative damage induced by hexavalent chromium in the heart of adult rats. Rats were divided into six groups. Group I served as controls and received standard diet. Group II received via drinking water potassium dichromate (K2Cr2O7) alone (700 ppm) during 3 weeks. Groups III and I...